SCNP identifies CLL donor subgroups by profiling functional immune signaling in the context of immune modulatory receptor expression

Background Antibody therapeutics targeting the Immune Modulatory Receptor (IMR) PD-1 have efficacy in multiple indications, and molecules targeting other IMRs are in development. Increased understanding of IMR biology is required to design rational combination therapies and identify biomarkers of response and toxicity. Here we applied Single Cell Network Profiling (SCNP) to assess functional signaling across immune cell subsets in the context of IMR expression, using PBMC of CLL and healthy donors (HD).